|Madhya-līlā||Chapter 24: The Sixty-One Explanations of the Ātmārāma Verse|
Bhaktivedanta VedaBase: Śrī Caitanya Caritāmṛta Madhya 24.16
'nirgrantha'-śabde kahe, avidyā-granthi-hīna
nirgrantha-śabde — by the word nirgrantha; kahe — one means; avidyā — of ignorance; granthi-hīna — without any knot; vidhi-niṣedha — regulative principles of rules and restrictions; veda-śāstra — the Vedic literature; jñāna-ādi — knowledge, and so on; vihīna — without.
"The word 'nirgrantha' refers to one who is liberated from the material knots of ignorance. It also refers to one who is devoid of all regulative principles enjoined in the Vedic literature. It also refers to one who does not have knowledge.
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His Divine Grace A. C. Bhaktivedanta Swami Prabhupāda, Founder Ācārya of the International Society for Krishna Consciousness